Language processing within the human medial temporal lobe
Identifieur interne : 000A08 ( Main/Exploration ); précédent : 000A07; suivant : 000A09Language processing within the human medial temporal lobe
Auteurs : Patric Meyer [Allemagne] ; Axel Mecklinger [Allemagne] ; Thomas Grunwald [Suisse, Allemagne] ; Juergen Fell [Allemagne] ; Christian E. Elger [Allemagne] ; Angela D. Friederici [Allemagne]Source :
- Hippocampus [ 1050-9631 ] ; 2005.
English descriptors
- KwdEn :
- Teeft :
- Amtl, Anterior negativity, Automatic manner, Basal ganglia, Brain potentials, Cogn, Cogn brain, Compelling evidence, Correct sentences, Cortex, Declarative memory, Declarative memory formation, Different aspects, Early time window, Electrode, Electrode contacts, Elger, Entorhinal cortex, Epilepsy, Epilepsy patients, Episodic memory, Erps, Experimental neuropsychology unit, Fernandez, Friederici, Gamma activity, Gamma band, Gamma oscillations, Gamma synchronization, Grunwald, Hippocampal, Hippocampal formation, Hippocampal lesions, Hippocampal recording sites, Hippocampal system, Hippocampus, Holcomb, Human medial, Incorrect condition, Incorrect sentences, Intracranial, Intracranial electrodes, Kutas, Language comprehension, Language processing, Late time window, Lesion, Lesion studies, Ller sentences, Lobe, Lobe epilepsy, Magnetic resonance imaging, Maximum amplitude, Medial, Memory formation, Memory systems, Neural basis, Neural generators, Neurosci, Noun, Noun phrase, Object perception, Oxford university press, Parahippocampal cortices, Parahippocampal region, Past participle, Perirhinal cortex, Phase synchronization, Phase synchronization values, Posterior portion, Prepositional phrase, Present study, Presurgical evaluation, Previous studies, Proc natl acad, Processing function, Processing functions, Recognition memory, Representational format, Rhinal, Rhinal cortex, Saarland university, Same sentence material, Semantic, Semantic integration, Semantic integration processes, Semantic memory, Semantic processes, Semantic violation, Semantic violations, Sentence comprehension, Sentence studies, Sentential context, Single items, Synchronization, Synchronization values, Syntactic, Syntactic anomaly, Syntactic complexity, Syntactic information, Syntactic integration, Syntactic processes, Syntactic processing, Syntactic violation, Syntactic violation condition, Syntactic violations, Temporal lobe, Time window, Time windows, Trends cogn, Verbal memory, Violation conditions.
Abstract
Although the hippocampal formation is essential for verbal memory, it is not fully understood how it contributes to language comprehension. We recorded event‐related potentials (ERPs) directly from two substructures of the medial temporal lobe (MTL), the rhinal cortex and the hippocampus proper, while epilepsy patients listened to sentences that either were correct or contained semantic or syntactic violations. Semantic violations elicited a large negative ERP response peaking at ∼400 ms in the rhinal cortex. In contrast, syntactically incorrect sentences elicited a negative deflection of 500–800 ms in the hippocampus proper. The results suggest that functionally distinct aspects of integration in language comprehension are supported by different MTL structures: the rhinal cortex is involved in semantic integration, whereas the hippocampus proper subserves processes of syntactic integration. An analysis of phase synchronization within the gamma band between rhinal and hippocampal recording sites showed that both of the above‐mentioned ERP components were preceded by an increase of phase synchronization. In contrast to these short phasic increases of phase synchronization in both violation conditions, correct sentences were associated with a long‐lasting synchronization in a late time window, possibly reflecting the integration of semantic and syntactic information as required for normal comprehension. © 2005 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/hipo.20070
Affiliations:
- Allemagne, Suisse
- District de Cologne, District de Leipzig, Rhénanie-du-Nord-Westphalie, Sarre (Land), Saxe (Land), Saxe-Anhalt
- Bonn, Leipzig, Magdebourg, Sarrebruck
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001964
- to stream Istex, to step Curation: 001844
- to stream Istex, to step Checkpoint: 000807
- to stream Main, to step Merge: 000A07
- to stream Main, to step Curation: 000A08
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Language processing within the human medial temporal lobe</title><author><name sortKey="Meyer, Patric" sort="Meyer, Patric" uniqKey="Meyer P" first="Patric" last="Meyer">Patric Meyer</name></author><author><name sortKey="Mecklinger, Axel" sort="Mecklinger, Axel" uniqKey="Mecklinger A" first="Axel" last="Mecklinger">Axel Mecklinger</name></author><author><name sortKey="Grunwald, Thomas" sort="Grunwald, Thomas" uniqKey="Grunwald T" first="Thomas" last="Grunwald">Thomas Grunwald</name></author><author><name sortKey="Fell, Juergen" sort="Fell, Juergen" uniqKey="Fell J" first="Juergen" last="Fell">Juergen Fell</name></author><author><name sortKey="Elger, Christian E" sort="Elger, Christian E" uniqKey="Elger C" first="Christian E." last="Elger">Christian E. Elger</name></author><author><name sortKey="Friederici, Angela D" sort="Friederici, Angela D" uniqKey="Friederici A" first="Angela D." last="Friederici">Angela D. Friederici</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:F46B081B4DBFD9B2E55A4C679792E177D180C713</idno><date when="2005" year="2005">2005</date><idno type="doi">10.1002/hipo.20070</idno><idno type="url">https://api.istex.fr/document/F46B081B4DBFD9B2E55A4C679792E177D180C713/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001964</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001964</idno><idno type="wicri:Area/Istex/Curation">001844</idno><idno type="wicri:Area/Istex/Checkpoint">000807</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000807</idno><idno type="wicri:doubleKey">1050-9631:2005:Meyer P:language:processing:within</idno><idno type="wicri:Area/Main/Merge">000A07</idno><idno type="wicri:Area/Main/Curation">000A08</idno><idno type="wicri:Area/Main/Exploration">000A08</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Language processing within the human medial temporal lobe</title><author><name sortKey="Meyer, Patric" sort="Meyer, Patric" uniqKey="Meyer P" first="Patric" last="Meyer">Patric Meyer</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychology, Experimental Neuropsychology Unit, Saarland University, Saarbrücken</wicri:regionArea><placeName><region type="land" nuts="2">Sarre (Land)</region><settlement type="city">Sarrebruck</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology II, Otto von Guericke University, Magdeburg</wicri:regionArea><placeName><region type="land" nuts="2">Saxe-Anhalt</region><settlement type="city">Magdebourg</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychology, Saarland University, Experimental Neuropsychology Unit, P.O. Box 15 11 50, Saarbrücken D‐66041</wicri:regionArea><placeName><region type="land" nuts="2">Sarre (Land)</region><settlement type="city">Sarrebruck</settlement></placeName></affiliation></author><author><name sortKey="Mecklinger, Axel" sort="Mecklinger, Axel" uniqKey="Mecklinger A" first="Axel" last="Mecklinger">Axel Mecklinger</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychology, Experimental Neuropsychology Unit, Saarland University, Saarbrücken</wicri:regionArea><placeName><region type="land" nuts="2">Sarre (Land)</region><settlement type="city">Sarrebruck</settlement></placeName></affiliation></author><author><name sortKey="Grunwald, Thomas" sort="Grunwald, Thomas" uniqKey="Grunwald T" first="Thomas" last="Grunwald">Thomas Grunwald</name><affiliation wicri:level="1"><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Epilepsy Center, Zurich</wicri:regionArea><wicri:noRegion>Zurich</wicri:noRegion></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Epileptology, University of Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Fell, Juergen" sort="Fell, Juergen" uniqKey="Fell J" first="Juergen" last="Fell">Juergen Fell</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Epileptology, University of Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Elger, Christian E" sort="Elger, Christian E" uniqKey="Elger C" first="Christian E." last="Elger">Christian E. Elger</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Epileptology, University of Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Friederici, Angela D" sort="Friederici, Angela D" uniqKey="Friederici A" first="Angela D." last="Friederici">Angela D. Friederici</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Leipzig</region><settlement type="city">Leipzig</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Hippocampus</title><title level="j" type="abbrev">Hippocampus</title><idno type="ISSN">1050-9631</idno><idno type="eISSN">1098-1063</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005">2005</date><biblScope unit="volume">15</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="451">451</biblScope><biblScope unit="page" to="459">459</biblScope></imprint><idno type="ISSN">1050-9631</idno></series><idno type="istex">F46B081B4DBFD9B2E55A4C679792E177D180C713</idno><idno type="DOI">10.1002/hipo.20070</idno><idno type="ArticleID">HIPO20070</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1050-9631</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>binding</term><term>hippocampus</term><term>rhinal cortex</term><term>semantics</term><term>syntax</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Amtl</term><term>Anterior negativity</term><term>Automatic manner</term><term>Basal ganglia</term><term>Brain potentials</term><term>Cogn</term><term>Cogn brain</term><term>Compelling evidence</term><term>Correct sentences</term><term>Cortex</term><term>Declarative memory</term><term>Declarative memory formation</term><term>Different aspects</term><term>Early time window</term><term>Electrode</term><term>Electrode contacts</term><term>Elger</term><term>Entorhinal cortex</term><term>Epilepsy</term><term>Epilepsy patients</term><term>Episodic memory</term><term>Erps</term><term>Experimental neuropsychology unit</term><term>Fernandez</term><term>Friederici</term><term>Gamma activity</term><term>Gamma band</term><term>Gamma oscillations</term><term>Gamma synchronization</term><term>Grunwald</term><term>Hippocampal</term><term>Hippocampal formation</term><term>Hippocampal lesions</term><term>Hippocampal recording sites</term><term>Hippocampal system</term><term>Hippocampus</term><term>Holcomb</term><term>Human medial</term><term>Incorrect condition</term><term>Incorrect sentences</term><term>Intracranial</term><term>Intracranial electrodes</term><term>Kutas</term><term>Language comprehension</term><term>Language processing</term><term>Late time window</term><term>Lesion</term><term>Lesion studies</term><term>Ller sentences</term><term>Lobe</term><term>Lobe epilepsy</term><term>Magnetic resonance imaging</term><term>Maximum amplitude</term><term>Medial</term><term>Memory formation</term><term>Memory systems</term><term>Neural basis</term><term>Neural generators</term><term>Neurosci</term><term>Noun</term><term>Noun phrase</term><term>Object perception</term><term>Oxford university press</term><term>Parahippocampal cortices</term><term>Parahippocampal region</term><term>Past participle</term><term>Perirhinal cortex</term><term>Phase synchronization</term><term>Phase synchronization values</term><term>Posterior portion</term><term>Prepositional phrase</term><term>Present study</term><term>Presurgical evaluation</term><term>Previous studies</term><term>Proc natl acad</term><term>Processing function</term><term>Processing functions</term><term>Recognition memory</term><term>Representational format</term><term>Rhinal</term><term>Rhinal cortex</term><term>Saarland university</term><term>Same sentence material</term><term>Semantic</term><term>Semantic integration</term><term>Semantic integration processes</term><term>Semantic memory</term><term>Semantic processes</term><term>Semantic violation</term><term>Semantic violations</term><term>Sentence comprehension</term><term>Sentence studies</term><term>Sentential context</term><term>Single items</term><term>Synchronization</term><term>Synchronization values</term><term>Syntactic</term><term>Syntactic anomaly</term><term>Syntactic complexity</term><term>Syntactic information</term><term>Syntactic integration</term><term>Syntactic processes</term><term>Syntactic processing</term><term>Syntactic violation</term><term>Syntactic violation condition</term><term>Syntactic violations</term><term>Temporal lobe</term><term>Time window</term><term>Time windows</term><term>Trends cogn</term><term>Verbal memory</term><term>Violation conditions</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although the hippocampal formation is essential for verbal memory, it is not fully understood how it contributes to language comprehension. We recorded event‐related potentials (ERPs) directly from two substructures of the medial temporal lobe (MTL), the rhinal cortex and the hippocampus proper, while epilepsy patients listened to sentences that either were correct or contained semantic or syntactic violations. Semantic violations elicited a large negative ERP response peaking at ∼400 ms in the rhinal cortex. In contrast, syntactically incorrect sentences elicited a negative deflection of 500–800 ms in the hippocampus proper. The results suggest that functionally distinct aspects of integration in language comprehension are supported by different MTL structures: the rhinal cortex is involved in semantic integration, whereas the hippocampus proper subserves processes of syntactic integration. An analysis of phase synchronization within the gamma band between rhinal and hippocampal recording sites showed that both of the above‐mentioned ERP components were preceded by an increase of phase synchronization. In contrast to these short phasic increases of phase synchronization in both violation conditions, correct sentences were associated with a long‐lasting synchronization in a late time window, possibly reflecting the integration of semantic and syntactic information as required for normal comprehension. © 2005 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Suisse</li></country><region><li>District de Cologne</li><li>District de Leipzig</li><li>Rhénanie-du-Nord-Westphalie</li><li>Sarre (Land)</li><li>Saxe (Land)</li><li>Saxe-Anhalt</li></region><settlement><li>Bonn</li><li>Leipzig</li><li>Magdebourg</li><li>Sarrebruck</li></settlement></list><tree><country name="Allemagne"><region name="Sarre (Land)"><name sortKey="Meyer, Patric" sort="Meyer, Patric" uniqKey="Meyer P" first="Patric" last="Meyer">Patric Meyer</name></region><name sortKey="Elger, Christian E" sort="Elger, Christian E" uniqKey="Elger C" first="Christian E." last="Elger">Christian E. Elger</name><name sortKey="Fell, Juergen" sort="Fell, Juergen" uniqKey="Fell J" first="Juergen" last="Fell">Juergen Fell</name><name sortKey="Friederici, Angela D" sort="Friederici, Angela D" uniqKey="Friederici A" first="Angela D." last="Friederici">Angela D. Friederici</name><name sortKey="Grunwald, Thomas" sort="Grunwald, Thomas" uniqKey="Grunwald T" first="Thomas" last="Grunwald">Thomas Grunwald</name><name sortKey="Mecklinger, Axel" sort="Mecklinger, Axel" uniqKey="Mecklinger A" first="Axel" last="Mecklinger">Axel Mecklinger</name><name sortKey="Meyer, Patric" sort="Meyer, Patric" uniqKey="Meyer P" first="Patric" last="Meyer">Patric Meyer</name><name sortKey="Meyer, Patric" sort="Meyer, Patric" uniqKey="Meyer P" first="Patric" last="Meyer">Patric Meyer</name></country><country name="Suisse"><noRegion><name sortKey="Grunwald, Thomas" sort="Grunwald, Thomas" uniqKey="Grunwald T" first="Thomas" last="Grunwald">Thomas Grunwald</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sarre/explor/MusicSarreV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A08 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000A08 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sarre
|area= MusicSarreV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:F46B081B4DBFD9B2E55A4C679792E177D180C713
|texte= Language processing within the human medial temporal lobe
}}
| This area was generated with Dilib version V0.6.33. |  |